Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 19/20 | 0.75 |
| ▸ | TLR9 | Q9NR96 | 19/20 | 0.75 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.69 |
| ▸ | TLR4 | O00206 | 2/20 | 0.69 |
| ▸ | TLR3 | O15455 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19838445 | 0.92 | TLR7 (0.78) | TLR7TLR9TLR8TLR4TLR3 | |
| SCHEMBL19839081 | 0.91 | TLR7 (0.79) | TLR7TLR9TLR8TLR4TLR3 | |
| SCHEMBL19838757 | 0.89 | TLR7 (0.82) | TLR7TLR9TLR8TLR4TLR3 | |
| SCHEMBL19838754 | 0.89 | TLR7 (0.75) | TLR7TLR9TLR8TLR4TLR3 | |
| SCHEMBL19838470 | 0.87 | TLR7 (0.81) | TLR7TLR9TLR8TLR4TLR3 | |
| SCHEMBL19839073 | 0.87 | TLR7 (0.73) | TLR7TLR9TLR8TLR4TLR3 | |
| SCHEMBL19839296 | 0.87 | TLR7 (0.91) | TLR7TLR9TLR8TLR4TLR3 | |
| SCHEMBL19839083 | 0.87 | TLR7 (0.78) | TLR7TLR9TLR8TLR4TLR3 | |
| SCHEMBL19838950 | 0.86 | TLR7 (1.00) | TLR7TLR9TLR8TLR4TLR3 | |
| SCHEMBL19838697 | 0.86 | TLR7 (1.00) | TLR7TLR9TLR8TLR4TLR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715617-B | Dimethoxyphenyl-substituted indole compounds as inhibitors of TLR7, TLR8 or TLR9 | 百时美施贵宝公司 | 2022-04-19 | — | — | CN | disclosed |