SCHEMBL28726669

NC(=O)OCC(NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N21)C(=O)NC(c1ccccc1)c1ccccc1

nearest known ligand 0.91

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	STAT3	P40763	12/20	0.91

▸	STAT1	P42224	1/20	0.91

▸	STAT4	Q14765	1/20	0.91

▸	STAT5A	P42229	2/20	0.43

▸	STAT5B	P51692	2/20	0.43

▸	CRBN	Q96SW2	2/20	0.42

▸	KDM5A	P29375	1/20	0.42

▸	KDM5B	Q9UGL1	1/20	0.42

▸	XIAP	P98170	4/20	0.39

▸	BIRC3	Q13489	4/20	0.39

▸	BIRC2	Q13490	4/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL28726668	1.00	STAT3 (0.91)	STAT3STAT1STAT4STAT5ASTAT5B
SCHEMBL30308587	1.00	STAT3 (0.91)	STAT3STAT1STAT4STAT5ASTAT5B
SCHEMBL30308498	0.95	STAT3 (1.00)	STAT3STAT1STAT4STAT5ASTAT5B
SCHEMBL22468771	0.95	STAT3 (1.00)	STAT3STAT1STAT4STAT5ASTAT5B
SCHEMBL30308610	0.95	STAT3 (1.00)	STAT3STAT1STAT4STAT5ASTAT5B
SCHEMBL25210244	0.95	STAT3 (1.00)	STAT3STAT1STAT4STAT5ASTAT5B
SCHEMBL25210237	0.95	STAT3 (1.00)	STAT3STAT1STAT4STAT5ASTAT5B
SCHEMBL22468769	0.95	STAT3 (1.00)	STAT3STAT1STAT4STAT5ASTAT5B
SCHEMBL30308404	0.95	STAT3 (1.00)	STAT3STAT1STAT4STAT5ASTAT5B
SCHEMBL25266660	0.95	STAT3 (0.83)	STAT3STAT1STAT4STAT5ASTAT5B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-114269763-A	Small molecule degradant for STAT3	美国密歇根州立大学试剂中心	2022-04-01	—	—	CN	disclosed