Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.43 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2403904 | 0.87 | GSK3B (0.75) | GSK3BBACE1CYP2D6 | |
| SCHEMBL5098175 | 0.84 | GSK3B (0.70) | GSK3BHTT | |
| SCHEMBL5561339 | 0.84 | GSK3B (0.64) | GSK3B | |
| SCHEMBL5104968 | 0.83 | GSK3B (0.69) | GSK3BHTT | |
| SCHEMBL5098141 | 0.83 | GSK3B (0.69) | GSK3BHTT | |
| SCHEMBL5105218 | 0.83 | GSK3B (0.52) | GSK3BLMNA | |
| SCHEMBL5038561 | 0.81 | GSK3B (0.62) | GSK3B | |
| SCHEMBL2403941 | 0.81 | GSK3B (0.62) | GSK3B | |
| SCHEMBL2401436 | 0.80 | GSK3B (0.61) | GSK3B | |
| SCHEMBL5096032 | 0.80 | GSK3B (0.61) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1247567-C | 2-amino-3-alkylpyrimidinone derivatives as GSK3 beta inhibitors | SANOFI AVENTIS (FR) | 2006-03-29 | — | — | CN | claimed |
| CN-1247567-C | 2-amino-3-alkylpyrimidinone derivatives as GSK3 beta inhibitors | SANOFI AVENTIS (FR) | 2006-03-29 | — | — | CN | disclosed |