Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.55 |
| ▸ | BUB1 | O43683 | 1/20 | 0.52 |
| ▸ | PRKACG | P22612 | 1/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.52 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.52 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.52 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27617224 | 0.89 | MAPK14 (0.56) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3406993 | 0.89 | MAPK14 (0.71) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL30336151 | 0.89 | MAPK14 (0.71) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL27598479 | 0.89 | MAPK14 (0.56) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL27598614 | 0.88 | MAPK14 (0.55) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL27598541 | 0.87 | MAPK14 (0.59) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL28963860 | 0.87 | MAPK14 (0.54) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL27598485 | 0.85 | MAPK14 (0.54) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL27598701 | 0.85 | MAPK14 (0.54) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL27598484 | 0.85 | MAPK14 (0.56) | MAPK14CYP2C9MAPK11BUB1PRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100369898-C | Nicotinamide derivates useful as p38 inhibitors | SMITHKLINE BEECHAM CORP (US) | 2008-02-20 | — | — | CN | claimed |
| CN-100369898-C | Nicotinamide derivates useful as p38 inhibitors | SMITHKLINE BEECHAM CORP (US) | 2008-02-20 | — | — | CN | disclosed |
| CN-1633416-A | Nicotinamide derivatives as p38 inhibitors | SMITHKLINE BEECHAM CORP (US) | 2005-06-29 | — | — | CN | disclosed |