Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | MAX | P61244 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29686658 | 1.00 | PRSS1 (0.46) | PRSS1AKR1C3AKR1C2AKR1C1PARP1 | |
| SCHEMBL19436449 | 0.86 | PRSS1 (0.40) | PRSS1PARP1LMNASMN1; SMN2POLB | |
| SCHEMBL29686241 | 0.86 | PRSS1 (0.40) | PRSS1PARP1LMNASMN1; SMN2POLB | |
| SCHEMBL29686597 | 0.85 | PRSS1 (0.40) | PRSS1PARP1LMNASMN1; SMN2POLB | |
| SCHEMBL28751945 | 0.85 | PRSS1 (0.40) | PRSS1PARP1LMNASMN1; SMN2POLB | |
| SCHEMBL22937053 | 0.82 | TSHR (0.42) | PRSS1 | |
| SCHEMBL26814609 | 0.82 | AR (0.51) | AKR1C3AKR1C2AKR1C1SMN1; SMN2ALDH1A1 | |
| SCHEMBL21643778 | 0.81 | SMN1; SMN2 (0.39) | PRSS1SMN1; SMN2POLBALDH1A1KDM4E | |
| SCHEMBL20876413 | 0.80 | MAPT (0.43) | PRSS1LMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL20876416 | 0.80 | MAPT (0.43) | PRSS1LMNASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114585623-A | Bis [ N- ((5-carbamoyl) -1H-benzo [ d ] imidazol-2-yl) pyrazole-5-carboxamide ] derivatives and related compounds as STING (interferon gene stimulator) agonists for the treatment of cancer | 梅尔莎纳医疗公司 | 2022-06-03 | — | — | CN | disclosed |