Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2880980 | 0.92 | IKBKB (0.35) | KDM4ERAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL3812197 | 0.90 | HPGD (0.33) | KDM4EHTTATMRAB9AALDH1A1 | |
| SCHEMBL2875206 | 0.86 | KDM4E (0.36) | KDM4EHTTATMRAB9AALDH1A1 | |
| SCHEMBL2876340 | 0.86 | KDM4E (0.35) | KDM4EHTTATMRAB9AALDH1A1 | |
| SCHEMBL3809451 | 0.85 | NPSR1 (0.40) | KDM4EHTTATMTSHRHSD17B10 | |
| SCHEMBL3816814 | 0.85 | KDM4E (0.39) | KDM4EHTTATMRAB9AALDH1A1 | |
| SCHEMBL3809123 | 0.85 | NPSR1 (0.40) | KDM4EHTTATMTSHRHSD17B10 | |
| SCHEMBL3808982 | 0.84 | KDM4E (0.34) | KDM4EHTTATMRAB9AALDH1A1 | |
| SCHEMBL3807257 | 0.84 | KDM4E (0.39) | KDM4EHTTATMRAB9AALDH1A1 | |
| SCHEMBL2879128 | 0.82 | HPGD (0.32) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569929-B9 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VIROCHEM PHARMA INC (CA) | 2011-09-14 | — | — | EP | claimed |
| EP-1569929-B1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VIROCHEM PHARMA INC (CA) | 2010-05-05 | — | — | EP | claimed |