Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 14/20 | 0.43 |
| ▸ | GPR183 | P32249 | 2/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.31 |
| ▸ | GLRB | P48167 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27625936 | 0.92 | CNR1 (0.42) | CNR1GPR183DRD5SLC6A2HTR2A | |
| SCHEMBL27625938 | 0.91 | CNR1 (0.53) | CNR1OPRM1OPRK1KMT2AALDH1A1 | |
| SCHEMBL27607338 | 0.86 | CNR1 (0.43) | CNR1GPR183DRD5SLC6A2HTR2A | |
| SCHEMBL28755841 | 0.81 | CNR1 (0.45) | CNR1GPR183DRD5SLC6A2HTR2A | |
| SCHEMBL4476817 | 0.80 | CNR1 (0.69) | CNR1GPR183KMT2AMEN1ALDH1A1 | |
| SCHEMBL4464890 | 0.70 | CNR1 (0.69) | CNR1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL4466755 | 0.69 | CNR1 (0.86) | CNR1ALDH1A1LMNAMAPT | |
| SCHEMBL4460616 | 0.69 | CNR1 (0.77) | CNR1ALDH1A1LMNAGAAMAPT | |
| SCHEMBL1317004 | 0.67 | CNR1 (0.64) | CNR1GPR183DRD5SLC6A2HTR2A | |
| SCHEMBL4461879 | 0.66 | CNR1 (0.67) | CNR1GPR183DRD5SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100486973-C | Novel benzodioxoles | HOFFMANN LA ROCHE (CH) | 2009-05-13 | — | — | CN | claimed |
| CN-1671684-A | New benzodioxoles | HOFFMANN LA ROCHE (CH) | 2005-09-21 | — | — | CN | claimed |
| CN-100486973-C | Novel benzodioxoles | HOFFMANN LA ROCHE (CH) | 2009-05-13 | — | — | CN | disclosed |
| CN-1671684-A | New benzodioxoles | HOFFMANN LA ROCHE (CH) | 2005-09-21 | — | — | CN | disclosed |