SCHEMBL28754156

SCHEMBL28754156

COC(=O)c1ccc(-c2nc(Nc3ccc(CN4CCN(OC(=O)C(C)(C)C)CC4)cc3)c3c(=O)[nH]ncc3n2)cc1

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SYK P43405 17/20 0.78
JAK2 O60674 10/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14716848 0.88 SYK (0.78) SYKJAK2
SCHEMBL14725192 0.88 SYK (1.00) SYKJAK2
Hydrochloric Acid SCHEMBL14716676 0.87 SYK (0.98) SYKJAK2
SCHEMBL28754015 0.87 SYK (0.84) SYKJAK2
Hydrochloric Acid SCHEMBL29635114 0.87 SYK (0.98) SYKJAK2
SCHEMBL14717035 0.80 SYK (1.00) SYKJAK2
SCHEMBL14725197 0.79 SYK (0.84) SYKJAK2
Hydrochloric Acid SCHEMBL14717593 0.78 SYK (0.82) SYKJAK2
SCHEMBL14720045 0.78 SYK (1.00) SYKJAK2
Hydrochloric Acid SCHEMBL14717389 0.77 SYK (0.98) SYKJAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108707151-B Pyrimido-pyridazinone compounds and uses thereof 阿萨纳生物科技有限责任公司 2022-06-03 CN disclosed