Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.73 |
| ▸ | JAK2 | O60674 | 4/20 | 0.73 |
| ▸ | KDR | P35968 | 3/20 | 0.73 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.73 |
| ▸ | CDK1 | P06493 | 2/20 | 0.73 |
| ▸ | ROS1 | P08922 | 2/20 | 0.73 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.73 |
| ▸ | CDK2 | P24941 | 2/20 | 0.73 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.73 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.73 |
| ▸ | CLK2 | P49760 | 2/20 | 0.73 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.73 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.73 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.73 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.73 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.73 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.73 |
| ▸ | LCK | P06239 | 2/20 | 0.73 |
| ▸ | SRC | P12931 | 2/20 | 0.73 |
| ▸ | CDC7 | O00311 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27088025 | 0.92 | RET (0.80) | RETJAK2KDRDYRK3CDK1 | |
| SCHEMBL29999054 | 0.88 | JAK2 (0.86) | RETJAK2KDRDYRK3CDK1 | |
| SCHEMBL24096480 | 0.88 | JAK2 (0.86) | RETJAK2KDRDYRK3CDK1 | |
| SCHEMBL28757083 | 0.86 | RET (0.60) | RETJAK2KDRDYRK3CDK1 | |
| Acetic Acid SCHEMBL30320621 | 0.85 | RET (0.73) | RETJAK2KDRDYRK3CDK1 | |
| SCHEMBL28423335 | 0.84 | RET (0.68) | RETJAK2KDRDYRK3CDK1 | |
| SCHEMBL17267662 | 0.84 | RET (0.68) | RETJAK2KDRDYRK3CDK1 | |
| SCHEMBL16594430 | 0.84 | RET (0.68) | RETJAK2KDRDYRK3CDK1 | |
| SCHEMBL6109435 | 0.84 | KDR (1.00) | RETJAK2KDRDYRK3CDK1 | |
| SCHEMBL6109045 | 0.84 | KDR (1.00) | RETJAK2KDRDYRK3CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114685516-A | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-108431007-B | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-06-07 | — | — | CN | disclosed |