Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 10/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27632415 | 0.93 | MCHR1 (0.42) | MCHR1TP53NPY5RADRA2ASMN1; SMN2 | |
| SCHEMBL27651724 | 0.90 | MCHR1 (0.40) | MCHR1TP53NPY5RADRA2ASMN1; SMN2 | |
| SCHEMBL27652700 | 0.89 | MCHR1 (0.42) | MCHR1NPY5RADRA2ASMN1; SMN2KDM4E | |
| SCHEMBL27632508 | 0.88 | MCHR1 (0.43) | MCHR1TP53NPY5RADRA2ASMN1; SMN2 | |
| SCHEMBL27651766 | 0.87 | MCHR1 (0.40) | MCHR1TP53NPY5RADRA2ASMN1; SMN2 | |
| SCHEMBL27632401 | 0.84 | MCHR1 (0.42) | MCHR1TP53NPY5RADRA2ASMN1; SMN2 | |
| SCHEMBL27632734 | 0.83 | MCHR1 (0.39) | MCHR1TP53NPY5RADRA2ASMN1; SMN2 | |
| SCHEMBL27631372 | 0.82 | MCHR1 (0.42) | MCHR1NPY5RADRA2ASMN1; SMN2KDM4E | |
| SCHEMBL27631409 | 0.81 | MCHR1 (0.43) | MCHR1TP53NPY5RADRA2ASMN1; SMN2 | |
| SCHEMBL27631408 | 0.81 | MCHR1 (0.43) | MCHR1TP53NPY5RADRA2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101475528-A | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO LTD (JP) | 2009-07-08 | — | — | CN | claimed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | claimed |
| CN-101475528-A | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO LTD (JP) | 2009-07-08 | — | — | CN | disclosed |
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |