SCHEMBL28757337

SCHEMBL28757337

CC(NN)c1ncnc2c(-c3ccc(Cl)cc3)c(-c3ccccc3Cl)nn12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FYN P06241 3/20 0.39
KMT2A Q03164 3/20 0.38
NPC1 O15118 2/20 0.38
MEN1 O00255 2/20 0.38
RAB9A P51151 1/20 0.38
CNR1 P21554 7/20 0.37
SRC P12931 3/20 0.36
CNR2 P34972 5/20 0.36
LYN P07948 2/20 0.35
BLK P51451 2/20 0.35
ABL1 P00519 2/20 0.35
CYP1A2 P05177 2/20 0.35
DAPK3 O43293 1/20 0.35
RIPK2 O43353 1/20 0.35
EGFR P00533 1/20 0.35
LCK P06239 1/20 0.35
YES1 P07947 1/20 0.35
HCK P08631 1/20 0.35
PDGFRB P09619 1/20 0.35
FGR P09769 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27633612 0.81 CNR1 (0.41) FYNKMT2ANPC1MEN1RAB9A
SCHEMBL4842601 0.80 SRC (0.41) FYNKMT2ANPC1MEN1RAB9A
SCHEMBL27633550 0.80 CNR1 (0.34) FYNKMT2ANPC1MEN1RAB9A
SCHEMBL27654390 0.79 CNR1 (0.43) FYNCNR1CNR2
SCHEMBL4833400 0.78 SRC (0.39) FYNKMT2ANPC1MEN1RAB9A
SCHEMBL4836443 0.73 CNR1 (0.43) FYNCNR1CNR2
SCHEMBL5380218 0.73 NPC1 (0.47) KMT2ANPC1MEN1RAB9ACNR1
SCHEMBL5377986 0.72 KMT2A (0.48) KMT2ANPC1MEN1RAB9ACNR1
SCHEMBL5380215 0.72 NPC1 (0.62) KMT2ANPC1MEN1RAB9AACVR1
SCHEMBL5375812 0.71 NPC1 (0.45) KMT2ANPC1MEN1RAB9ACNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1768061-A Pyrazolo[1,5-a][1,3,5]triazine derivatives as cannabinoid receptor ligands PFIZER PROD INC (US) 2006-05-03 CN disclosed