Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | GLA | P06280 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.56 |
| ▸ | RELA | Q04206 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL506665 | 0.88 | KDM4E (0.62) | KDM4ESMN1; SMN2MAPTGLAGAA | |
| SCHEMBL28265561 | 0.85 | SMN1; SMN2 (0.59) | KDM4ESMN1; SMN2MAPTGLAGAA | |
| SCHEMBL27638532 | 0.84 | S1PR1 (0.52) | KDM4ESMN1; SMN2MAPTGLAGAA | |
| SCHEMBL28265577 | 0.82 | KDM4E (0.56) | KDM4ESMN1; SMN2MAPTGLAGAA | |
| SCHEMBL10230259 | 0.81 | KDM4E (0.62) | KDM4ESMN1; SMN2MAPTGLAGAA | |
| SCHEMBL12967444 | 0.81 | SMN1; SMN2 (0.62) | KDM4ESMN1; SMN2MAPTGLAGAA | |
| SCHEMBL507537 | 0.81 | KDM4E (0.67) | KDM4ESMN1; SMN2MAPTGLAGAA | |
| SCHEMBL12596887 | 0.81 | APP (0.68) | KDM4ESMN1; SMN2MAPTGLAGAA | |
| SCHEMBL12596888 | 0.81 | KDM4E (0.62) | KDM4ESMN1; SMN2MAPTGLAGAA | |
| SCHEMBL27652217 | 0.79 | TDP1 (0.42) | KDM4ESMN1; SMN2MAPTGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102329267-A | 6-substituted 2,3,4, 5-tetrahydro-1H-benzo [d] aza as 5-HT2Creceptor agonists | LILLY CO ELI | 2012-01-25 | — | — | CN | disclosed |
| CN-102311387-A | 6-substituted 2,3,4, 5-tetrahydro-1H-benzo [d] aza as 5-HT2Creceptor agonists | LILLY CO ELI | 2012-01-11 | — | — | CN | disclosed |
| CN-1934088-A | As 5-HT2c6-substituted 2,3,4, 5-tetrahydro-1H-benzo [ d ] receptor agonists]Aza * | LILLY CO ELI (US) | 2007-03-21 | — | — | CN | disclosed |