Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 14/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 13/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867789 | 1.00 | MCHR1 (0.46) | MCHR1ADRA2ASIGMAR1ADRA1AHRH1 | |
| SCHEMBL6878486 | 0.90 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6878481 | 0.90 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6873809 | 0.88 | MCHR1 (0.44) | MCHR1ADRA2ASIGMAR1ADRA1AHRH1 | |
| SCHEMBL6458745 | 0.88 | MCHR1 (0.42) | MCHR1ADRA2ASIGMAR1ADRA1AHRH1 | |
| SCHEMBL6458749 | 0.88 | MCHR1 (0.42) | MCHR1ADRA2ASIGMAR1ADRA1AHRH1 | |
| SCHEMBL6873813 | 0.88 | MCHR1 (0.44) | MCHR1ADRA2ASIGMAR1ADRA1AHRH1 | |
| SCHEMBL6831524 | 0.87 | MCHR1 (0.45) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6831523 | 0.87 | MCHR1 (0.45) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6876384 | 0.87 | MCHR1 (0.45) | MCHR1ADRA2AADRA1AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |