Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.50 |
| ▸ | FLT3 | P36888 | 7/20 | 0.50 |
| ▸ | CSF1R | P07333 | 3/20 | 0.35 |
| ▸ | KIT | P10721 | 3/20 | 0.35 |
| ▸ | FLT1 | P17948 | 3/20 | 0.35 |
| ▸ | FLT4 | P35916 | 3/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 2/20 | 0.31 |
| ▸ | BLK | P51451 | 2/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27791588 | 0.88 | KDR (0.55) | KDRFLT3KITDYRK1A | |
| SCHEMBL27657289 | 0.79 | KDR (0.47) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL27812408 | 0.79 | KDR (0.44) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL27812416 | 0.78 | KDR (0.49) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL27657298 | 0.78 | KDR (0.54) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL28757593 | 0.77 | KDR (0.53) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL27636462 | 0.77 | KDR (0.60) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL27791478 | 0.76 | KDR (0.56) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL27812410 | 0.76 | KDR (0.56) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL3362570 | 0.75 | KDR (0.51) | KDRFLT3CSF1RKITFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102417487-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB | 2012-04-18 | — | — | CN | claimed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | claimed |
| CN-102417487-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB | 2012-04-18 | — | — | CN | disclosed |
| CN-1826324-B | indazole, Benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-12-07 | — | — | CN | disclosed |
| CN-101827584-A | Solid dispersion product of N-aryl ureido drugs | ABBOTT GMBH & CO KG | 2010-09-08 | — | — | CN | disclosed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | disclosed |