Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.45 |
| ▸ | FLT3 | P36888 | 4/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | FYN | P06241 | 2/20 | 0.45 |
| ▸ | LYN | P07948 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | MARK3 | P27448 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | BLK | P51451 | 2/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.45 |
| ▸ | STK3 | Q13188 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.45 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27682773 | 0.92 | EPHX2 (0.46) | KDRAURKBFLT3NTRK1LCK | |
| SCHEMBL13463238 | 0.90 | KDR (0.47) | KDRAURKBFLT3NTRK1LCK | |
| SCHEMBL27663144 | 0.88 | TEK (0.53) | KDRAURKBFLT3NTRK1LCK | |
| SCHEMBL27663171 | 0.87 | KDR (0.53) | KDRAURKBFLT3NTRK1LCK | |
| SCHEMBL27663240 | 0.87 | KDR (0.48) | KDRAURKBFLT3NTRK1LCK | |
| SCHEMBL13437469 | 0.86 | KDR (0.51) | KDRAURKBFLT3NTRK1LCK | |
| SCHEMBL3620355 | 0.86 | KDR (0.45) | KDRAURKBFLT3NTRK1LCK | |
| SCHEMBL3621931 | 0.85 | AURKB (0.49) | KDRAURKBFLT3NTRK1LCK | |
| SCHEMBL3612230 | 0.84 | AURKB (0.48) | KDRAURKBFLT3NTRK1LCK | |
| SCHEMBL27682735 | 0.83 | KDR (0.49) | KDRAURKBFLT3NTRK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1993361-B | Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER PHARMACEUTICALS CORP | 2010-05-26 | — | — | CN | disclosed |
| CN-1993361-A | Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER PHARMACEUTICALS CORP (US) | 2007-07-04 | — | — | CN | disclosed |