Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27668260 | 0.82 | LRRK2 (0.57) | LRRK2MAP2K1RAF1XDHEGFR | |
| SCHEMBL3883564 | 0.81 | SRC (0.39) | LRRK2MAP3K7TAB1XDHEGFR | |
| SCHEMBL20178365 | 0.80 | LRRK2 (0.54) | LRRK2MAP2K1RAF1EGFRERBB2 | |
| SCHEMBL27668255 | 0.80 | LRRK2 (0.48) | LRRK2MAP2K1RAF1AAK1XDH | |
| SCHEMBL27668505 | 0.79 | LRRK2 (0.50) | LRRK2MAP2K1RAF1AAK1EGFR | |
| SCHEMBL3891428 | 0.78 | SRC (0.38) | LRRK2MAP3K7TAB1XDHSRC | |
| SCHEMBL27668262 | 0.77 | LRRK2 (0.57) | LRRK2MAP2K1RAF1ELANEAAK1 | |
| SCHEMBL6913366 | 0.77 | CYP2D6 (0.48) | ELANEMAP3K7TAB1XDH | |
| SCHEMBL7231410 | 0.75 | MAP2K1 (0.61) | LRRK2MAP2K1RAF1ALDH1A1SRC | |
| SCHEMBL16134182 | 0.74 | LRRK2 (0.61) | LRRK2MAP2K1RAF1EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1976927-A | Quinoline thiazolinone compound | HOFFMANN LA ROCHE (CH) | 2007-06-06 | — | — | CN | disclosed |