Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2874610 | 1.00 | HRH3 (0.52) | HRH3CYP3A4CYP2C9ABL1LCK | |
| SCHEMBL519944 | 1.00 | HRH3 (0.52) | HRH3CYP3A4CYP2C9ABL1LCK | |
| SCHEMBL22852294 | 0.84 | CYP2D6 (0.57) | HRH3CYP3A4CYP2C9SLC18A3CYP2D6 | |
| SCHEMBL22852288 | 0.84 | CYP2D6 (0.62) | HRH3CYP3A4CYP2C9SLC18A3CYP2D6 | |
| SCHEMBL22852296 | 0.84 | CYP2D6 (0.57) | HRH3CYP3A4CYP2C9SLC18A3CYP2D6 | |
| SCHEMBL22852297 | 0.84 | CYP2D6 (0.62) | HRH3CYP3A4CYP2C9SLC18A3CYP2D6 | |
| SCHEMBL22852275 | 0.84 | CYP2D6 (0.62) | HRH3CYP3A4CYP2C9SLC18A3CYP2D6 | |
| SCHEMBL22852264 | 0.84 | CYP2D6 (0.57) | HRH3CYP3A4CYP2C9SLC18A3CYP2D6 | |
| SCHEMBL3515888 | 0.84 | SLC18A3 (0.60) | HRH3CYP3A4CYP2C9SLC18A3CYP2D6 | |
| SCHEMBL10836464 | 0.83 | HRH3 (0.52) | HRH3CYP3A4CYP2C9IRAK4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053897-A1 | COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2011-03-03 | — | — | US | disclosed |
| EP-1811998-B1 | TRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2010-10-20 | — | — | EP | disclosed |
| US-7645775-B2 | Triazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-01-12 | — | — | US | disclosed |
| US-20070270410-A1 | Triazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-11-22 | — | — | US | disclosed |
| EP-1811998-A1 | TRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006047256-A1 | TRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053897-A1 | COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS | SYK, BTK, LYN | HRH3 2764/4885CYP3A4 4647/4885CYP2C9 4826/4885 |
| US-20070270410-A1 | Triazoles useful as inhibitors of protein kinases | MAP3K20, MAP3K3, MAP3K1 | HRH3 2005/4885CYP3A4 3279/4885CYP2C9 4080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.