Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 20/20 | 0.77 |
| ▸ | CHUK | O15111 | 6/20 | 0.77 |
| ▸ | BTK | Q06187 | 2/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4688449 | 0.88 | IKBKB (0.98) | IKBKBCHUKBTKCSF1RAURKA | |
| SCHEMBL4687061 | 0.87 | IKBKB (0.80) | IKBKBCHUKBTKCSF1RAURKA | |
| SCHEMBL3797172 | 0.87 | IKBKB (0.80) | IKBKBCHUKBTKCSF1RAURKA | |
| SCHEMBL4688652 | 0.87 | IKBKB (0.80) | IKBKBCHUKBTKCSF1RAURKA | |
| SCHEMBL3796938 | 0.87 | IKBKB (1.00) | IKBKBCHUKBTKCSF1RAURKA | |
| SCHEMBL4688211 | 0.84 | IKBKB (0.75) | IKBKBCHUKBTKCSF1RAURKA | |
| SCHEMBL4689143 | 0.84 | IKBKB (0.75) | IKBKBCHUKBTKCSF1RAURKA | |
| SCHEMBL552003 | 0.83 | IKBKB (0.81) | IKBKBCHUKBTKCSF1RAURKA | |
| SCHEMBL4686015 | 0.83 | IKBKB (0.92) | IKBKBCHUKBTKCSF1RAURKA | |
| SCHEMBL27678461 | 0.82 | IKBKB (0.68) | IKBKBCHUKBTKCSF1RAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1933830-A | Indole derivatives and their use as kinase inhibitors, in particular IKK2 inhibitors | SMITHKLINE BEECHAM CORP (US) | 2007-03-21 | — | — | CN | disclosed |