Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 7/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28767438 | 0.89 | FGFR3 (0.42) | FGFR3CYP3A4CYP2C19FGFR4FGFR1 | |
| SCHEMBL16659627 | 0.81 | FGFR3 (0.33) | FGFR3CYP3A4CYP2C19FGFR4FGFR1 | |
| SCHEMBL17740814 | 0.80 | FGFR4 (0.49) | FGFR3FGFR4FGFR1FGFR2 | |
| SCHEMBL28767434 | 0.80 | FGFR1 (0.33) | FGFR3CYP3A4CYP2C19FGFR4FGFR1 | |
| SCHEMBL16654102 | 0.79 | FGFR4 (0.32) | FGFR3CYP3A4CYP2C19FGFR4FGFR1 | |
| SCHEMBL16654740 | 0.79 | FGFR4 (0.48) | FGFR3CYP3A4CYP2C19FGFR4FGFR1 | |
| SCHEMBL16665253 | 0.78 | FGFR1 (0.33) | FGFR3CYP3A4CYP2C19FGFR4FGFR1 | |
| SCHEMBL17740813 | 0.78 | FGFR4 (0.65) | FGFR3FGFR4FGFR1FGFR2 | |
| SCHEMBL16659545 | 0.77 | FGFR1 (0.52) | FGFR3CYP3A4CYP2C19FGFR4FGFR1 | |
| SCHEMBL17728850 | 0.77 | FGFR1 (0.46) | FGFR3CYP3A4CYP2C19FGFR4FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109422760-B | FGFR4 inhibitor and application thereof | 南京圣和药物研发有限公司 | 2022-05-27 | — | — | CN | disclosed |