4,4'-Methylenedianiline

4,4'-Methylenedianiline

SCHEMBL2877004

Nc1ccc(Cc2ccc(N)cc2)cc1.Nc1ccccc1Cc1ccccc1N

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.61
ALDH1A1 P00352 1/20 0.61
TSHR P16473 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
MAOB P27338 4/20 0.46
MAOA P21397 2/20 0.46
HTR6 P50406 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
CYP17A1 P05093 1/20 0.44
CYP19A1 P11511 1/20 0.44
CYP11B1 P15538 1/20 0.44
CYP11B2 P19099 1/20 0.44
GFER P55789 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.41
HTR2A P28223 1/20 0.41
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
CA14 Q9ULX7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18203488 0.96 CYP3A4 (0.54) CYP3A4ALDH1A1TSHRTDP1MAOB
4,4'-Methylenedianiline SCHEMBL5189841 0.96 CYP3A4 (0.61) CYP3A4ALDH1A1TSHRTDP1MAOB
SCHEMBL29372857 0.93 CYP3A4 (0.56) CYP3A4ALDH1A1TSHRTDP1MAOB
SCHEMBL39484 0.93 CYP3A4 (0.56) CYP3A4ALDH1A1TSHRTDP1MAOB
SCHEMBL2782720 0.91 CYP3A4 (0.45) CYP3A4ALDH1A1TSHRTDP1MAOB
SCHEMBL9665442 0.89 CYP3A4 (0.48) CYP3A4ALDH1A1TSHRTDP1MAOB
SCHEMBL36019 0.83 CYP3A4 (0.53) CYP3A4ALDH1A1TSHRTDP1L3MBTL1
SCHEMBL29373097 0.83 CYP3A4 (0.53) CYP3A4ALDH1A1TSHRTDP1L3MBTL1
SCHEMBL10422322 0.83 CYP3A4 (0.50) CYP3A4ALDH1A1TSHRTDP1MAOB
SCHEMBL486603 0.81 CYP3A4 (0.65) CYP3A4ALDH1A1TSHRTDP1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7790268-B2 Circuit materials, multilayer circuits, and methods of manufacture thereof WORLD PROPERTIES, INC. (US) 2010-09-07 US disclosed
WO-2008127970-A2 CIRCUIT MATERIALS, MULTILAYER CIRCUITS, AND METHODS OF MANUFACTURE THEREOF WORLD PROPERTIES, INC. (US) 2008-10-23 WO disclosed
US-20080254313-A1 CIRCUIT MATERIALS, MULTILAYER CIRCUITS, AND METHODS OF MANUFACTURE THEREOF JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT 2008-10-16 US disclosed
US-5214212-A Salt of transition or lanthanide metal as a promoter, reaction of methylenedianiline to produce corresponding cyclohexyl compound OLIN CORPORATION (US) 1993-05-25 US disclosed