Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | F12 | P00748 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18154055 | 0.98 | PLAU (0.43) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL11349520 | 0.81 | PLAU (0.43) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL11349521 | 0.81 | PLAU (0.43) | PLAUCYP2A6F12NCF1NOS3 | |
| Bromide SCHEMBL299632 | 0.79 | PLAU (0.44) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL23886136 | 0.79 | PLAU (0.47) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL29373584 | 0.77 | PLAU (0.46) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL131316 | 0.77 | PLAU (0.46) | PLAUCYP2A6F12NCF1NOS3 | |
| Bromide SCHEMBL1122418 | 0.77 | PLAU (0.48) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL22883707 | 0.76 | PLAU (0.39) | PLAUCYP2A6F12NCF1NOS3 | |
| Hydrochloric Acid SCHEMBL2222537 | 0.76 | PLAU (0.44) | PLAUCYP2A6F12NCF1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114599341-A | External skin preparation for cellulite improvement and method for improving cellulite | 东洋精糖株式会社 | 2022-06-07 | — | — | CN | disclosed |