Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20028915 | 1.00 | USP30 (0.46) | USP30HPGDUSP2SMN1; SMN2MEN1 | |
| SCHEMBL1441490 | 0.84 | USP30 (0.46) | USP30HPGDUSP2SMN1; SMN2MEN1 | |
| SCHEMBL11931444 | 0.84 | MEN1 (0.53) | USP30HPGDUSP2SMN1; SMN2MEN1 | |
| SCHEMBL20028676 | 0.84 | USP30 (0.45) | USP30HPGDUSP2SMN1; SMN2MEN1 | |
| SCHEMBL1439256 | 0.84 | USP30 (0.45) | USP30HPGDUSP2SMN1; SMN2MEN1 | |
| SCHEMBL19995401 | 0.82 | USP30 (0.42) | USP30HPGDUSP2SMN1; SMN2MEN1 | |
| SCHEMBL662017 | 0.81 | USP30 (0.42) | USP30HPGDUSP2SMN1; SMN2MEN1 | |
| SCHEMBL28564135 | 0.80 | HPGD (0.41) | USP30HPGDUSP2SMN1; SMN2MEN1 | |
| SCHEMBL21145360 | 0.80 | USP30 (0.49) | USP30HPGDUSP2SMN1; SMN2MEN1 | |
| SCHEMBL1262593 | 0.79 | HPGD (0.45) | USP30HPGDUSP2SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109790148-B | Cyano-substituted heterocycles having USP30 inhibitor activity | 特殊治疗有限公司 | 2022-06-07 | — | — | CN | disclosed |