Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.78 |
| ▸ | IDH2 | P48735 | 17/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20289567 | 1.00 | IDH1 (0.78) | IDH1IDH2 | |
| SCHEMBL30274607 | 1.00 | IDH1 (0.78) | IDH1IDH2 | |
| SCHEMBL31206531 | 0.95 | IDH1 (0.77) | IDH1IDH2 | |
| SCHEMBL30274578 | 0.95 | IDH1 (0.77) | IDH1IDH2 | |
| SCHEMBL22879073 | 0.95 | IDH1 (0.77) | IDH1IDH2 | |
| SCHEMBL22879083 | 0.92 | IDH1 (0.65) | IDH1IDH2 | |
| SCHEMBL25170990 | 0.90 | IDH1 (0.79) | IDH1IDH2 | |
| SCHEMBL22572279 | 0.90 | IDH1 (0.79) | IDH1IDH2 | |
| SCHEMBL23343408 | 0.90 | IDH1 (0.79) | IDH1IDH2 | |
| SCHEMBL20289761 | 0.90 | IDH1 (0.79) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115109075-A | Mutant IDH1 and IDH2 inhibitors | 伊莱利利公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-110072867-B | 7-phenylethylamino-4H-pyrimido [4,5-D ] [1,3] oxazin-2-one compounds as inhibitors of mutant IDH1 and IDH2 | 伊莱利利公司 | 2022-07-08 | — | — | CN | disclosed |