Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 19/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL188533 | 0.85 | PIK3CG (0.55) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL27823122 | 0.84 | PIK3CG (0.35) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL188502 | 0.77 | PIK3CG (0.72) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL184946 | 0.77 | PIK3CG (0.69) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL189404 | 0.76 | PIK3CG (0.71) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL188885 | 0.76 | PIK3CG (0.56) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL188987 | 0.76 | PIK3CG (0.67) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL1791075 | 0.76 | PIK3CG (0.68) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL188887 | 0.76 | PIK3CG (0.57) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL189087 | 0.76 | PIK3CG (0.68) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528231-A | Use of PI3K and MEK modulators in the treatment of cancer | EXELIXIS INC (US) | 2009-09-09 | — | — | CN | disclosed |