Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.70 |
| ▸ | USP2 | O75604 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | THRB | P10828 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CCNC | P24863 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1883629 | 0.99 | MAPT (0.69) | MAPTKMT2AUSP2ALDH1A1THRB | |
| SCHEMBL17675323 | 0.85 | KMT2A (0.72) | MAPTKMT2AUSP2ALDH1A1THRB | |
| SCHEMBL7617075 | 0.83 | MAPT (0.63) | MAPTKMT2AUSP2ALDH1A1THRB | |
| SCHEMBL19124864 | 0.83 | MAPT (1.00) | MAPTKMT2AUSP2ALDH1A1THRB | |
| SCHEMBL13335886 | 0.83 | KMT2A (0.85) | MAPTKMT2AUSP2ALDH1A1THRB | |
| SCHEMBL12218062 | 0.82 | MAPT (0.79) | MAPTKMT2AUSP2ALDH1A1THRB | |
| Hydrochloric Acid SCHEMBL1884132 | 0.82 | MAPT (0.79) | MAPTKMT2AUSP2ALDH1A1THRB | |
| Hydrochloric Acid SCHEMBL1884322 | 0.82 | MAPT (0.79) | MAPTKMT2AUSP2ALDH1A1THRB | |
| SCHEMBL12218074 | 0.81 | MAPT (0.72) | MAPTKMT2AUSP2ALDH1A1THRB | |
| Hydrochloric Acid SCHEMBL1890987 | 0.81 | MAPT (0.78) | MAPTKMT2AUSP2ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101889008-A | Be used to regulate the quinoline of dna methylation | SUPERGEN INC | 2010-11-17 | — | — | CN | disclosed |
| CN-101535295-A | Quinoline derivatives for modulating DNA methylation | SUPERGEN INC (US) | 2009-09-16 | — | — | CN | disclosed |