Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | PRKACG | P22612 | 1/20 | 0.36 |
| ▸ | PRKACB | P22694 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447063 | 0.87 | LIMK2 (0.52) | NPSR1LIMK2KMT2AMEN1LIMK1 | |
| SCHEMBL27760911 | 0.84 | NPSR1 (0.56) | NPSR1RAB9ALIMK2SMN1; SMN2HSD17B10 | |
| SCHEMBL28784009 | 0.84 | TACR1 (0.44) | NPSR1RAB9ALIMK2SMN1; SMN2FAAH | |
| SCHEMBL28780152 | 0.81 | NPSR1 (0.47) | NPSR1RAB9ALIMK2SMN1; SMN2HSD17B10 | |
| SCHEMBL27760806 | 0.81 | NPSR1 (0.55) | NPSR1RAB9ALIMK2SMN1; SMN2HSD17B10 | |
| SCHEMBL27761055 | 0.75 | NPSR1 (0.45) | NPSR1RAB9ASMN1; SMN2FAAHTRPV1 | |
| SCHEMBL1446897 | 0.74 | LIMK2 (0.48) | LIMK2LIMK1ROCK2ROCK1PRKACA | |
| SCHEMBL1447618 | 0.73 | LIMK2 (0.60) | NPSR1LIMK2KMT2AMEN1LIMK1 | |
| SCHEMBL1446861 | 0.72 | LIMK2 (0.47) | LIMK2LIMK1ROCK2ROCK1PRKACA | |
| SCHEMBL1446649 | 0.71 | LIMK2 (0.57) | NPSR1LIMK2KMT2AMEN1LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101565420-A | LIMK2 inhibitors, compositions comprising them, and methods of their use | LEXICON PHARMACEUTICALS INC (US) | 2009-10-28 | — | — | CN | disclosed |