Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.56 |
| ▸ | JAK2 | O60674 | 7/20 | 0.45 |
| ▸ | BRD4 | O60885 | 7/20 | 0.45 |
| ▸ | STAT6 | P42226 | 5/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | CDK4 | P11802 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1657571 | 0.85 | RPS6KA3 (0.50) | RPS6KA3JAK2BRD4STAT6AURKA | |
| SCHEMBL27824886 | 0.84 | RPS6KA3 (0.64) | RPS6KA3JAK2BRD4STAT6AURKA | |
| SCHEMBL27824864 | 0.82 | RPS6KA3 (0.62) | RPS6KA3JAK2BRD4STAT6AURKA | |
| SCHEMBL27803985 | 0.81 | RPS6KA3 (0.56) | RPS6KA3JAK2BRD4STAT6AURKA | |
| SCHEMBL28790439 | 0.79 | STAT6 (0.61) | RPS6KA3JAK2BRD4STAT6AURKA | |
| SCHEMBL28786504 | 0.77 | RPS6KA3 (0.40) | RPS6KA3JAK2BRD4JAK1BRD2 | |
| SCHEMBL27804077 | 0.75 | STAT6 (0.56) | RPS6KA3JAK2BRD4STAT6AURKA | |
| SCHEMBL28790308 | 0.73 | STAT6 (0.53) | RPS6KA3JAK2BRD4STAT6CDK4 | |
| SCHEMBL1654507 | 0.72 | RPS6KA3 (0.56) | RPS6KA3JAK2BRD4STAT6AURKA | |
| SCHEMBL25016925 | 0.72 | RPS6KA3 (1.00) | RPS6KA3JAK2BRD4STAT6AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101981036-A | Pyrrolo [2, 3-D] pyridines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG | 2011-02-23 | — | — | CN | claimed |