Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL331348 | 0.94 | PDE5A (0.71) | PDE5AKCNH2 | |
| SCHEMBL2870991 | 0.93 | PDE5A (0.70) | PDE5AKCNH2 | |
| SCHEMBL332082 | 0.93 | PDE5A (0.79) | PDE5AKCNH2 | |
| SCHEMBL332820 | 0.93 | PDE5A (0.79) | PDE5AKCNH2 | |
| SCHEMBL331941 | 0.91 | PDE5A (0.68) | PDE5AKCNH2 | |
| SCHEMBL331300 | 0.91 | PDE5A (0.68) | PDE5AKCNH2 | |
| SCHEMBL331742 | 0.90 | PDE5A (0.69) | PDE5AKCNH2 | |
| Pf-00489791 SCHEMBL331279 | 0.89 | PDE5A (1.00) | PDE5AKCNH2 | |
| Pf-00489791 SCHEMBL29379715 | 0.89 | PDE5A (1.00) | PDE5AKCNH2 | |
| SCHEMBL4704463 | 0.89 | PDE5A (0.78) | PDE5AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689751-B1 | 5,7-DIAMINOPYRAZOLO[4,3-D]PYRIMIDINES WITH PDE-5 INHIBITING ACTIVITY | PFIZER LTD (GB) | 2010-10-20 | — | — | EP | claimed |
| US-8796288-B2 | Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide | PFIZER INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-8796287-B2 | Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide | PFIZER INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-8796287-B2 | Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide | PFIZER INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-20120214827-A1 | Anhydrous Crystalline Forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide | PFIZER INC. (US) | 2012-08-23 | — | — | US | disclosed |
| US-20120214827-A1 | Anhydrous Crystalline Forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide | PFIZER INC. (US) | 2012-08-23 | — | — | US | disclosed |
| US-20120208830-A1 | Anhydrous Crystalline Forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide | PFIZER INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-8227475-B2 | Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide | PFIZER INC. (US) | 2012-07-24 | — | — | US | disclosed |
| US-8227475-B2 | Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide | PFIZER INC. (US) | 2012-07-24 | — | — | US | disclosed |
| US-8227475-B2 | Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide | PFIZER INC. (US) | 2012-07-24 | — | — | US | disclosed |
| EP-1881985-B1 | ANHYDROUS CRYSTALLINE FORMS OF N-Ý1-(2-ETHOXYETHYL)-5-(N-ETHYL-N-METHYLAMINO)-7-(4-METHYLPYRIDIN-2-YL-AMINO)-1H-PYRAZOLO[4,3-D]PYRIMIDINE-3-CARBONYL¨METHANESULFONAMIDE | PFIZER (US) | 2010-12-29 | — | — | EP | disclosed |
| EP-1881985-B1 | ANHYDROUS CRYSTALLINE FORMS OF N-Ý1-(2-ETHOXYETHYL)-5-(N-ETHYL-N-METHYLAMINO)-7-(4-METHYLPYRIDIN-2-YL-AMINO)-1H-PYRAZOLO[4,3-D]PYRIMIDINE-3-CARBONYL¨METHANESULFONAMIDE | PFIZER (US) | 2010-12-29 | — | — | EP | disclosed |
| US-20080194591-A1 | Phosphodiesterase inhibitor | PFIZER INC. | 2008-08-14 | — | — | US | disclosed |
| US-20080194591-A1 | Phosphodiesterase inhibitor | PFIZER INC. | 2008-08-14 | — | — | US | disclosed |
| US-20080194591-A1 | Phosphodiesterase inhibitor | PFIZER INC. | 2008-08-14 | — | — | US | disclosed |
| WO-2006120552-A2 | ANHYDROUS CRYSTALLINE FORMS OF N-[1-(2-ETHOXYETHYL)-5-(N-ETHYL-N-METHYLAMINO)-7-(4-METHYLPYRIDIN-2-yl-AMINO)-1H-PYRAZOLO[4,3-d]PYRIMIDINE-3-CARBONYL]METHANESULFONAMIDE | PFIZER INC. (US) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194591-A1 | Phosphodiesterase inhibitor | PDE5A, PDE3B, PDE3A | PDE5A 1/4885KCNH2 485/4885 |
| US-20120214827-A1 | Anhydrous Crystalline Forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide | PDE5A, PDE3A, PDE3B | PDE5A 1/4885KCNH2 446/4885 |
| US-20120208830-A1 | Anhydrous Crystalline Forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide | PDE5A, PDE3A, PDE3B | PDE5A 1/4885KCNH2 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.