Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 19/20 | 0.76 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.72 |
| ▸ | PRKACA | P17612 | 4/20 | 0.72 |
| ▸ | CDK2 | P24941 | 4/20 | 0.72 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.72 |
| ▸ | GSK3B | P49841 | 3/20 | 0.72 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.72 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.72 |
| ▸ | PIM1 | P11309 | 3/20 | 0.72 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.72 |
| ▸ | AURKA | O14965 | 3/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.59 |
| ▸ | PRKCG | P05129 | 3/20 | 0.59 |
| ▸ | CDK1 | P06493 | 3/20 | 0.59 |
| ▸ | MARK3 | P27448 | 3/20 | 0.59 |
| ▸ | AKT1 | P31749 | 3/20 | 0.59 |
| ▸ | AKT2 | P31751 | 3/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.59 |
| ▸ | GSK3A | P49840 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669567 | 0.90 | CDC7 (0.88) | CDC7ROCK2PRKACACDK2MAP4K4 | |
| SCHEMBL3667584 | 0.90 | CDC7 (0.73) | CDC7ROCK2PRKACACDK2MAP4K4 | |
| SCHEMBL3671100 | 0.89 | CDC7 (0.78) | CDC7ROCK2PRKACACDK2MAP4K4 | |
| SCHEMBL3665767 | 0.88 | CDC7 (0.72) | CDC7ROCK2PRKACACDK2MAP4K4 | |
| SCHEMBL3675478 | 0.88 | CDC7 (0.75) | CDC7ROCK2PRKACACDK2MAP4K4 | |
| SCHEMBL4289897 | 0.88 | CDC7 (0.70) | CDC7ROCK2PRKACACDK2MAP4K4 | |
| SCHEMBL3667572 | 0.88 | CDC7 (0.85) | CDC7ROCK2PRKACACDK2MAP4K4 | |
| SCHEMBL3673674 | 0.88 | CDC7 (0.78) | CDC7ROCK2PRKACACDK2MAP4K4 | |
| SCHEMBL3666591 | 0.87 | CDC7 (0.74) | CDC7ROCK2PRKACACDK2MAP4K4 | |
| SCHEMBL3669810 | 0.87 | CDC7 (0.72) | CDC7ROCK2PRKACACDK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101790526-A | 5-heteroaryl substituted indazoles as kinase inhibitors | ABBOTT GMBH & CO KG | 2010-07-28 | — | — | CN | claimed |
| CN-101790526-A | 5-heteroaryl substituted indazoles as kinase inhibitors | ABBOTT GMBH & CO KG | 2010-07-28 | — | — | CN | disclosed |