Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27797715 | 0.85 | KLKB1 (0.41) | KLKB1LMNAMAPK14HPGDFAAH | |
| SCHEMBL2211336 | 0.78 | HPGD (0.53) | LMNAHPGDADORA2AALDH1A1PKM | |
| SCHEMBL4189968 | 0.78 | MEN1 (0.48) | LMNAADORA2AALDH1A1PKMGRM5 | |
| SCHEMBL15019980 | 0.78 | NOTUM (0.43) | MAPK14HPGDFAAHPKMGRM5 | |
| SCHEMBL27840071 | 0.76 | KLKB1 (0.40) | KLKB1LMNAMAPK14ADORA2ALOXL2 | |
| SCHEMBL27759677 | 0.74 | KLKB1 (0.38) | KLKB1LMNAMAPK14ENPP2LOXL2 | |
| SCHEMBL27818962 | 0.74 | KLKB1 (0.38) | KLKB1LMNAMAPK14ENPP2LOXL2 | |
| SCHEMBL27840078 | 0.74 | KLKB1 (0.38) | KLKB1LMNAMAPK14ENPP2LOXL2 | |
| SCHEMBL27988017 | 0.73 | GRM5 (0.56) | HPGDALDH1A1GRM5RAB9A | |
| SCHEMBL27797713 | 0.73 | ATM (0.47) | KLKB1LMNAMAPK14HPGDLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101896480-A | Tetrazole derivatives as modulators of metabotropic glutamate receptors (MGLURS) | ASTRAZENECA AB | 2010-11-24 | — | — | CN | claimed |