Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 12/20 | 0.65 |
| ▸ | CDK9 | P50750 | 6/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.53 |
| ▸ | CDC7 | O00311 | 5/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 5/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.53 |
| ▸ | PRKACA | P17612 | 5/20 | 0.53 |
| ▸ | CLK2 | P49760 | 5/20 | 0.53 |
| ▸ | CDK7 | P50613 | 5/20 | 0.53 |
| ▸ | PRKX | P51817 | 5/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.53 |
| ▸ | PAK4 | O96013 | 4/20 | 0.53 |
| ▸ | PIM1 | P11309 | 4/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.53 |
| ▸ | GSK3B | P49841 | 4/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.53 |
| ▸ | CDK8 | P49336 | 4/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1456733 | 0.84 | PDPK1 (0.64) | PDPK1CDK9CDK5ROCK1CDC7 | |
| SCHEMBL1603775 | 0.84 | PDPK1 (0.72) | PDPK1CDK9CDK5ROCK1CDC7 | |
| SCHEMBL1457288 | 0.81 | PDPK1 (0.61) | PDPK1CDK9CDK5ROCK1CDC7 | |
| SCHEMBL1604736 | 0.80 | PDPK1 (0.74) | PDPK1CDK9CDK5ROCK1CDC7 | |
| SCHEMBL1604217 | 0.79 | PDPK1 (1.00) | PDPK1CDK9CDK5ROCK1CDC7 | |
| SCHEMBL1603523 | 0.78 | PDPK1 (1.00) | PDPK1CDK9CDK5ROCK1CDC7 | |
| SCHEMBL1604071 | 0.78 | PDPK1 (0.78) | PDPK1CDK9CDK5ROCK1CDC7 | |
| SCHEMBL1456489 | 0.78 | PDPK1 (0.62) | PDPK1CDK9CDK5ROCK1CDC7 | |
| SCHEMBL1604041 | 0.78 | PDPK1 (1.00) | PDPK1CDK9CDK5ROCK1CDC7 | |
| SCHEMBL1603855 | 0.78 | PDPK1 (0.81) | PDPK1CDK9CDK5ROCK1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102056926-B | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH | 2013-10-16 | — | — | CN | claimed |
| CN-102056926-A | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH | 2011-05-11 | — | — | CN | claimed |
| CN-102056926-B | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH | 2013-10-16 | — | — | CN | disclosed |
| CN-102056926-A | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH | 2011-05-11 | — | — | CN | disclosed |