Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.63 |
| ▸ | FLT3 | P36888 | 9/20 | 0.48 |
| ▸ | FLT1 | P17948 | 8/20 | 0.48 |
| ▸ | FLT4 | P35916 | 8/20 | 0.48 |
| ▸ | PLK4 | O00444 | 4/20 | 0.48 |
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.48 |
| ▸ | CDK1 | P06493 | 4/20 | 0.48 |
| ▸ | PRKACA | P17612 | 4/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.48 |
| ▸ | AKT1 | P31749 | 4/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.48 |
| ▸ | STK3 | Q13188 | 4/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.48 |
| ▸ | MARK2 | Q7KZI7 | 4/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27636556 | 0.86 | KDR (0.77) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL27657361 | 0.86 | KDR (0.62) | KDRFLT3FLT1FLT4PLK4 | |
| Acetic Acid SCHEMBL27785089 | 0.85 | KDR (0.75) | KDRFLT3FLT1FLT4PLK4 | |
| Toluene SCHEMBL27811422 | 0.85 | KDR (0.77) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL27636400 | 0.82 | KDR (0.62) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL27657356 | 0.81 | KDR (0.61) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL27657313 | 0.81 | KDR (0.60) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL27636471 | 0.81 | KDR (0.60) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL4739159 | 0.80 | KDR (0.78) | KDRFLT3FLT1FLT4PLK4 | |
| SCHEMBL27636381 | 0.79 | KDR (0.58) | KDRFLT3FLT1FLT4PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102417487-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB | 2012-04-18 | — | — | CN | disclosed |