Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPA1 | O60313 | 1/20 | 0.87 |
| ▸ | EIF5B | O60841 | 1/20 | 0.87 |
| ▸ | MET | P08581 | 1/20 | 0.87 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.87 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CCND1 | P24385 | 2/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2879812 | 1.00 | OPA1 (0.87) | OPA1EIF5BMETHMOX2HTR2A | |
| SCHEMBL3114656 | 1.00 | OPA1 (0.87) | OPA1EIF5BMETHMOX2HTR2A | |
| SCHEMBL3120542 | 1.00 | OPA1 (0.87) | OPA1EIF5BMETHMOX2HTR2A | |
| Tivantinib SCHEMBL44944 | 0.93 | OPA1 (1.00) | OPA1EIF5BMETHMOX2HTR2A | |
| Tivantinib SCHEMBL45306 | 0.93 | OPA1 (1.00) | OPA1EIF5BMETHMOX2HTR2A | |
| Tivantinib SCHEMBL14865187 | 0.93 | OPA1 (1.00) | OPA1EIF5BMETHMOX2HTR2A | |
| Tivantinib SCHEMBL1395795 | 0.93 | OPA1 (1.00) | OPA1EIF5BMETHMOX2HTR2A | |
| Tivantinib SCHEMBL224883 | 0.93 | OPA1 (1.00) | OPA1EIF5BMETHMOX2HTR2A | |
| Tivantinib SCHEMBL44902 | 0.93 | OPA1 (1.00) | OPA1EIF5BMETHMOX2HTR2A | |
| Tivantinib SCHEMBL29355700 | 0.93 | OPA1 (1.00) | OPA1EIF5BMETHMOX2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170870-A1 | PYRROLIDINONE, PYRROLIDINE-2, 5-DIONE, PYRROLIDINE AND THIOSUCCINIMIDE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER | ArQule, Inc. (US) | 2010-04-07 | — | — | EP | claimed |
| WO-2009002806-A1 | PYRROLIDINONE, PYRROLIDINE-2, 5-DIONE, PYRROLIDINE AND THIOSUCCINIMIDE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER | ARQULE, INC. (US) | 2008-12-31 | — | — | WO | claimed |
| EP-2170870-A1 | PYRROLIDINONE, PYRROLIDINE-2, 5-DIONE, PYRROLIDINE AND THIOSUCCINIMIDE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER | ArQule, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009002806-A1 | PYRROLIDINONE, PYRROLIDINE-2, 5-DIONE, PYRROLIDINE AND THIOSUCCINIMIDE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER | ARQULE, INC. (US) | 2008-12-31 | — | — | WO | disclosed |