Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 10/20 | 0.88 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 3/20 | 0.40 |
| ▸ | RPA1 | P27694 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9893643 | 0.94 | MDM2 (0.88) | MDM2NOTUMGRM5KMORPA1 | |
| SCHEMBL9893724 | 0.93 | MDM2 (1.00) | MDM2NOTUMKMORPA1HTR2A | |
| SCHEMBL27879077 | 0.93 | MDM2 (0.88) | MDM2NOTUMHTR2AHTR2CSLC6A4 | |
| SCHEMBL1437176 | 0.90 | MDM2 (0.90) | MDM2NOTUMKMORPA1HTR2A | |
| SCHEMBL1437096 | 0.89 | MDM2 (0.79) | MDM2NOTUMGRM5KMORPA1 | |
| SCHEMBL28796349 | 0.89 | MDM2 (0.83) | MDM2NOTUMKMOHTR2AHTR2C | |
| SCHEMBL1437130 | 0.89 | MDM2 (0.86) | MDM2NOTUMKMORPA1HTR2A | |
| SCHEMBL9893854 | 0.87 | MDM2 (0.77) | MDM2NOTUMGRM5KMORPA1 | |
| SCHEMBL9893845 | 0.87 | MDM2 (0.79) | MDM2NOTUMKMORPA1 | |
| SCHEMBL27862924 | 0.87 | MDM2 (0.66) | MDM2KMORPA1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574785-A | Tetra-substituted heteroaryl compounds and their use as MDM2 and/or MDM4 modulators | NOVARTIS AG | 2012-07-11 | — | — | CN | disclosed |