Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 8/20 | 0.53 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.36 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.36 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 2/20 | 0.34 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.33 |
| ▸ | CCKAR | P32238 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27862841 | 0.88 | MDM2 (0.67) | MDM2CD38GPR52NOTUMCASP1 | |
| SCHEMBL1437078 | 0.87 | MDM2 (0.63) | MDM2SLC16A3SLC16A1TRPV3NOTUM | |
| SCHEMBL27879055 | 0.87 | MDM2 (0.60) | MDM2CD38GPR52NOTUMCASP1 | |
| SCHEMBL27879063 | 0.84 | MDM2 (0.56) | MDM2CD38GPR52NOTUMCASP1 | |
| SCHEMBL28799381 | 0.84 | MDM2 (0.54) | MDM2CD38CASP1 | |
| SCHEMBL27879068 | 0.83 | MDM2 (0.51) | MDM2GPR52CASP1 | |
| SCHEMBL1437076 | 0.82 | MDM2 (0.75) | MDM2SLC16A3SLC16A1TRPV3NOTUM | |
| SCHEMBL28796354 | 0.82 | MDM2 (0.67) | MDM2CD38NOTUM | |
| SCHEMBL27862926 | 0.82 | MDM2 (0.54) | MDM2CD38GPR52NOTUMCASP1 | |
| SCHEMBL9893939 | 0.80 | MDM2 (0.54) | MDM2SLC16A3SLC16A1TRPV3NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574785-A | Tetra-substituted heteroaryl compounds and their use as MDM2 and/or MDM4 modulators | NOVARTIS AG | 2012-07-11 | — | — | CN | disclosed |