Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 14/20 | 0.59 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27862805 | 0.84 | MDM2 (0.43) | MDM2 | |
| SCHEMBL9893574 | 0.83 | MDM2 (0.68) | MDM2NR1H4KCNH2 | |
| SCHEMBL27879316 | 0.83 | MDM2 (0.63) | MDM2CNR1NR1H4MAPTNPSR1 | |
| SCHEMBL1444255 | 0.80 | MDM2 (0.62) | MDM2MAPTNPSR1 | |
| SCHEMBL9893934 | 0.80 | MDM2 (0.62) | MDM2MAPTNPSR1 | |
| Lithium SCHEMBL9894073 | 0.76 | MDM2 (0.73) | MDM2CNR1CNR2 | |
| SCHEMBL9894071 | 0.76 | MDM2 (0.73) | MDM2CNR1CNR2 | |
| SCHEMBL9893775 | 0.76 | MDM2 (0.62) | MDM2MAPTNPSR1 | |
| SCHEMBL9893723 | 0.75 | MDM2 (1.00) | MDM2KMO | |
| SCHEMBL1437225 | 0.75 | MDM2 (0.56) | MDM2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574785-A | Tetra-substituted heteroaryl compounds and their use as MDM2 and/or MDM4 modulators | NOVARTIS AG | 2012-07-11 | — | — | CN | disclosed |