Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 12/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 9/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 9/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 3/20 | 0.39 |
| ▸ | CSNK2A3 | Q8NEV1 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2872878 | 0.91 | SMN1; SMN2 (0.41) | JAK2CSNK2A1CSNK2A2CSNK2BPIM1 | |
| SCHEMBL2872275 | 0.87 | JAK2 (0.46) | JAK2CSNK2A1CSNK2A2CSNK2BPIM1 | |
| SCHEMBL2879272 | 0.84 | JAK2 (0.67) | JAK2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL2879275 | 0.84 | JAK2 (0.67) | JAK2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3501794 | 0.77 | JAK2 (0.62) | JAK2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3501790 | 0.77 | JAK2 (0.62) | JAK2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL13225304 | 0.75 | JAK2 (0.68) | JAK2 | |
| SCHEMBL3500129 | 0.72 | JAK2 (0.70) | JAK2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3500133 | 0.72 | JAK2 (0.70) | JAK2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3502677 | 0.72 | JAK2 (0.43) | JAK2CSNK2A1CSNK2A2CSNK2BPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | claimed |