Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 3/20 | 0.47 |
| ▸ | GRN | P28799 | 1/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1600235 | 0.75 | CDK8 (0.52) | CDK8GRNSORT1MAPK14MAPK11 | |
| SCHEMBL1600233 | 0.74 | GRN (0.80) | CDK8GRNSORT1MAPK14MAPK11 | |
| SCHEMBL287168 | 0.72 | CDK8 (0.52) | CDK8GRNSORT1MAPK14MAPK11 | |
| SCHEMBL4248001 | 0.71 | PPARA (0.40) | CDK8GRNSORT1MAPK14MAPK11 | |
| SCHEMBL1600309 | 0.70 | CDK8 (0.82) | CDK8MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL12983908 | 0.69 | TRPV1 (0.61) | TRPV1 | |
| SCHEMBL1600591 | 0.69 | GRN (0.62) | CDK8GRNSORT1MAPK14MAPK11 | |
| SCHEMBL12506458 | 0.68 | TRPV1 (0.62) | MAPK14MAPK11MAPK13MAPK12TRPV1 | |
| SCHEMBL15948863 | 0.68 | GRN (0.61) | CDK8GRNSORT1MAPK14MAPK11 | |
| SCHEMBL1599781 | 0.68 | CDK8 (0.54) | CDK8GRNSORT1MAPK14MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102596941-A | Compounds for the treatment of dyslipidemia and related diseases | CADILA HEALTHCARE LTD | 2012-07-18 | — | — | CN | claimed |
| CN-102596941-A | Compounds for the treatment of dyslipidemia and related diseases | CADILA HEALTHCARE LTD | 2012-07-18 | — | — | CN | disclosed |