Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 10/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.43 |
| ▸ | YES1 | P07947 | 5/20 | 0.43 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL629147 | 0.95 | MAPK1 (0.46) | MAPK1AURKBYES1HIPK1PIM1 | |
| SCHEMBL628841 | 0.87 | MAPK1 (0.45) | MAPK1AURKBYES1HIPK1PIM1 | |
| SCHEMBL629704 | 0.84 | ABL1 (0.45) | MAPK1AURKBYES1HIPK1PIM1 | |
| SCHEMBL629121 | 0.82 | MAPK1 (0.51) | MAPK1AURKBYES1HIPK1PIM1 | |
| SCHEMBL629647 | 0.82 | MAPK1 (0.42) | MAPK1AURKBYES1HIPK1PIM1 | |
| SCHEMBL630421 | 0.82 | MAPK1 (0.42) | MAPK1AURKBYES1HIPK1PIM1 | |
| SCHEMBL629037 | 0.82 | MAPK1 (0.61) | MAPK1AURKBYES1HIPK1PIM1 | |
| SCHEMBL629296 | 0.81 | MAPK1 (0.46) | MAPK1AURKBYES1HIPK1PIM1 | |
| SCHEMBL629176 | 0.81 | MAPK1 (0.49) | MAPK1AURKBYES1HIPK1PIM1 | |
| SCHEMBL629375 | 0.80 | MAPK1 (0.48) | MAPK1AURKBYES1HIPK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102378758-A | Quinoxaline derivatives and their use for treating benign and malignant tumour disorders | AETERNA ZENTARIS GMBH | 2012-03-14 | — | — | CN | disclosed |