Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 13/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28805605 | 0.89 | GRM4 (0.40) | GRM4NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL28802187 | 0.88 | GRM4 (0.37) | GRM4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL458109 | 0.83 | GRM4 (0.50) | GRM4NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL28805579 | 0.77 | GPR6 (0.34) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL458121 | 0.76 | NPC1 (0.47) | GRM4NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL459718 | 0.71 | NAMPT (0.42) | GRM4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL30686047 | 0.69 | GRM4 (0.65) | GRM4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL10415452 | 0.69 | GRM4 (0.65) | GRM4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL28805581 | 0.69 | SRD5A2 (0.32) | — | |
| SCHEMBL460017 | 0.68 | PDGFRB (0.49) | NPC1RAB9AMAPTPKMOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103080086-B | Prostaglandin D synthase inhibitory piperidine compounds | TAIHO PHARMACEUTICAL CO LTD | 2014-11-05 | — | — | CN | claimed |
| CN-103080086-B | Prostaglandin D synthase inhibitory piperidine compounds | TAIHO PHARMACEUTICAL CO LTD | 2014-11-05 | — | — | CN | disclosed |
| CN-103080086-A | Prostaglandin D synthase inhibitory piperidine compounds | TAIHO PHARMACEUTICAL CO LTD | 2013-05-01 | — | — | CN | disclosed |