Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.79 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.79 |
| ▸ | AKT2 | P31751 | 7/20 | 0.79 |
| ▸ | AKT3 | Q9Y243 | 7/20 | 0.79 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.79 |
| ▸ | LATS1 | O95835 | 2/20 | 0.79 |
| ▸ | PRKCB | P05771 | 2/20 | 0.79 |
| ▸ | RET | P07949 | 2/20 | 0.79 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.79 |
| ▸ | PRKCA | P17252 | 2/20 | 0.79 |
| ▸ | PRKACA | P17612 | 2/20 | 0.79 |
| ▸ | PRKACB | P22694 | 2/20 | 0.79 |
| ▸ | GRK2 | P25098 | 2/20 | 0.79 |
| ▸ | CLK1 | P49759 | 2/20 | 0.79 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.79 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.79 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.79 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.79 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.79 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15809880 | 1.00 | AKT1 (0.79) | AKT1ROCK2AKT2AKT3PRKD3 | |
| SCHEMBL20544778 | 0.95 | AKT1 (0.79) | AKT1ROCK2AKT2AKT3PRKD3 | |
| SCHEMBL20544918 | 0.93 | AKT1 (0.79) | AKT1ROCK2AKT2AKT3PRKD3 | |
| SCHEMBL392547 | 0.93 | AKT1 (0.78) | AKT1ROCK2AKT2AKT3PRKD3 | |
| SCHEMBL20544757 | 0.92 | AKT1 (0.78) | AKT1ROCK2AKT2AKT3PRKD3 | |
| SCHEMBL20544493 | 0.91 | AKT1 (0.80) | AKT1ROCK2AKT2AKT3PRKD3 | |
| SCHEMBL20545432 | 0.91 | AKT1 (0.79) | AKT1ROCK2AKT2AKT3PRKD3 | |
| SCHEMBL19415115 | 0.91 | AKT1 (0.80) | AKT1ROCK2AKT2AKT3PRKD3 | |
| SCHEMBL20544743 | 0.91 | AKT1 (0.80) | AKT1ROCK2AKT2AKT3PRKD3 | |
| SCHEMBL20544734 | 0.91 | AKT1 (0.80) | AKT1ROCK2AKT2AKT3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101861321-B | Pyrrolo [2, 3 -D] pyrimidin derivatives as protein kinase B inhibitors | ASTRAZENECA AB | 2013-02-06 | — | — | CN | claimed |