Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | PTAFR | P25105 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | P2RY10 | O00398 | 5/20 | 0.39 |
| ▸ | PLA2G2C | Q5R387 | 2/20 | 0.39 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28853370 | 0.84 | FABP3 (0.45) | FABP3ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL1468007 | 0.77 | TSHR (0.44) | TSHR | |
| SCHEMBL3448811 | 0.77 | PLA2G2C (0.48) | FABP3TSHRP2RY10PLA2G2CGPR34 | |
| Choline SCHEMBL27911876 | 0.76 | LPAR3 (0.34) | FABP3ADRA1DPTAFRHTR1DHTR2C | |
| Choline SCHEMBL28025633 | 0.76 | TSHR (0.36) | FABP3ADRA1DPTAFRHTR1DHTR2C | |
| Ammonia Solution, Strong SCHEMBL18140161 | 0.76 | TSHR (0.43) | TSHR | |
| SCHEMBL27898158 | 0.75 | TSHR (0.40) | TSHR | |
| SCHEMBL28595957 | 0.74 | TSHR (0.60) | FABP3ADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL15302991 | 0.72 | TSHR (0.56) | TSHRPLA2G2C | |
| SCHEMBL27660620 | 0.72 | TSHR (0.56) | TSHRPLA2G2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102941073-B | Preparation method and application of bionic phospholipid membrane monolithic column | UNIV JINAN | 2014-12-31 | — | — | CN | claimed |
| CN-102941073-A | Preparation method and application of bionic phospholipid membrane monolithic column | UNIV JINAN | 2013-02-27 | — | — | CN | claimed |
| CN-102941073-B | Preparation method and application of bionic phospholipid membrane monolithic column | UNIV JINAN | 2014-12-31 | — | — | CN | disclosed |
| CN-102941073-A | Preparation method and application of bionic phospholipid membrane monolithic column | UNIV JINAN | 2013-02-27 | — | — | CN | disclosed |