Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.35 |
| ▸ | MTOR | P42345 | 7/20 | 0.32 |
| ▸ | AKT1 | P31749 | 3/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | EEF2K | O00418 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28806931 | 0.87 | PDE5A (0.36) | PIK3CA | |
| SCHEMBL28806935 | 0.86 | ADORA2A (0.43) | — | |
| SCHEMBL27932477 | 0.83 | PIK3CA (0.34) | PIK3CA | |
| SCHEMBL27932436 | 0.83 | ADORA2A (0.34) | PIK3CAMTOR | |
| SCHEMBL27914295 | 0.83 | ADORA2A (0.35) | — | |
| SCHEMBL876961 | 0.74 | EEF2K (0.34) | PIK3CAMTORAKT1EEF2K | |
| SCHEMBL872452 | 0.73 | ADA (0.42) | PIK3CAMTOR | |
| SCHEMBL874071 | 0.72 | EEF2K (0.36) | PIK3CAMTORAKT1EEF2K | |
| SCHEMBL27932435 | 0.69 | ADORA2A (0.42) | — | |
| SCHEMBL27932391 | 0.68 | ADORA2A (0.40) | MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103261202-A | Fused tricyclic compounds as adenosine receptor antagonist | ADVINUS THERAPEUTICS LTD | 2013-08-21 | — | — | CN | disclosed |