Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.82 |
| ▸ | CSF1R | P07333 | 2/20 | 0.76 |
| ▸ | KDR | P35968 | 6/20 | 0.70 |
| ▸ | KIT | P10721 | 3/20 | 0.70 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.70 |
| ▸ | FLT1 | P17948 | 1/20 | 0.70 |
| ▸ | FLT4 | P35916 | 1/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | FYN | P06241 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
| ▸ | LTK | P29376 | 1/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27942045 | 0.94 | EGFR (0.74) | EGFRCSF1RKDRKITPDGFRB | |
| SCHEMBL27923388 | 0.91 | EGFR (0.74) | EGFRCSF1RKDRKITPDGFRB | |
| SCHEMBL27942030 | 0.90 | EGFR (0.73) | EGFRCSF1RKDRKITPDGFRB | |
| SCHEMBL27923378 | 0.89 | FYN (0.73) | EGFRCSF1RKDRKITPDGFRB | |
| SCHEMBL27758517 | 0.88 | EGFR (0.76) | EGFRCSF1RKDRKITPDGFRB | |
| SCHEMBL27942042 | 0.87 | EGFR (0.69) | EGFRCSF1RKDRKITPDGFRB | |
| SCHEMBL27758535 | 0.87 | AURKB (0.68) | EGFRCSF1RAURKAFYNSRC | |
| SCHEMBL22548260 | 0.87 | CSF1R (1.00) | EGFRCSF1RKDRKITPDGFRB | |
| SCHEMBL27942167 | 0.87 | EGFR (0.68) | EGFRCSF1RKDRKITPDGFRB | |
| SCHEMBL27923375 | 0.86 | EGFR (0.67) | EGFRCSF1RKDRAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103382182-A | Phenylurea coupling quinazoline compound, and preparation method, pharmaceutical composition and pharmaceutical use thereof | UNIV HEBEI MEDICAL | 2013-11-06 | — | — | CN | claimed |
| CN-103382182-A | Phenylurea coupling quinazoline compound, and preparation method, pharmaceutical composition and pharmaceutical use thereof | UNIV HEBEI MEDICAL | 2013-11-06 | — | — | CN | disclosed |