Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 16/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.54 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.54 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | MAP3K9 | P80192 | 2/20 | 0.51 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.51 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | FGR | P09769 | 1/20 | 0.51 |
| ▸ | FER | P16591 | 1/20 | 0.51 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TEC | P42680 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27943082 | 0.86 | MTOR (0.68) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL17555342 | 0.86 | MTOR (0.67) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL27943076 | 0.84 | MTOR (0.63) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4445564 | 0.84 | MTOR (0.70) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4441057 | 0.84 | MTOR (0.75) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4441460 | 0.83 | MTOR (0.68) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4435386 | 0.81 | MTOR (0.66) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4439910 | 0.81 | PIK3CA (0.69) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL17571345 | 0.81 | MTOR (0.78) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4556110 | 0.81 | MTOR (0.78) | MTORPIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101675053-B | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH INC | 2014-03-12 | — | — | CN | claimed |
| CN-101675053-B | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH INC | 2014-03-12 | — | — | CN | disclosed |