Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 17/20 | 0.74 |
| ▸ | HTR2A | P28223 | 16/20 | 0.74 |
| ▸ | HTR2B | P41595 | 14/20 | 0.74 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.63 |
| ▸ | CNR1 | P21554 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | HRH1 | P35367 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1094635 | 0.85 | HTR2A (1.00) | HTR2CHTR2AHTR2BSLC6A4ADRB1 | |
| SCHEMBL1094393 | 0.85 | HTR2A (1.00) | HTR2CHTR2AHTR2BSLC6A4ADRB1 | |
| SCHEMBL1094636 | 0.85 | HTR2A (1.00) | HTR2CHTR2AHTR2BSLC6A4ADRB1 | |
| Lorcaserin SCHEMBL29349440 | 0.78 | HTR2A (1.00) | HTR2CHTR2AHTR2BSLC6A4ADRB1 | |
| Lorcaserin SCHEMBL1094953 | 0.78 | HTR2A (1.00) | HTR2CHTR2AHTR2BSLC6A4ADRB1 | |
| Lorcaserin SCHEMBL5946555 | 0.78 | HTR2A (1.00) | HTR2CHTR2AHTR2BSLC6A4ADRB1 | |
| Lorcaserin SCHEMBL170848 | 0.78 | HTR2A (1.00) | HTR2CHTR2AHTR2BSLC6A4ADRB1 | |
| Lorcaserin SCHEMBL169382 | 0.78 | HTR2A (1.00) | HTR2CHTR2AHTR2BSLC6A4ADRB1 | |
| SCHEMBL1095853 | 0.76 | HTR2A (0.69) | HTR2CHTR2AHTR2BSLC6A4ADRB1 | |
| Lorcaserin SCHEMBL174044 | 0.76 | HTR2A (0.97) | HTR2CHTR2AHTR2BSLC6A4ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015591-B | Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-choro-i-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine | ARENA PHARM INC | 2014-01-29 | — | — | CN | disclosed |