SCHEMBL28809706

SCHEMBL28809706

CNC(=O)CC(C)(C)[C]=O

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 1/20 0.39
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL681118 0.74
SCHEMBL7346515 0.72
SCHEMBL4282052 0.72
SCHEMBL116713 0.72
SCHEMBL16092680 0.72 HMGCR (0.50) MCL1LMNA
SCHEMBL13544816 0.71 MCL1 (0.34) MCL1LMNA
SCHEMBL13544542 0.71 KDM4E (0.48) MCL1LMNA
SCHEMBL9925425 0.71 MCL1 (0.42) MCL1LMNA
SCHEMBL24920461 0.70 MCL1 (0.37) MCL1LMNA
SCHEMBL16378718 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103664973-A Spiro-oxindole compounds and their use as therapeutic agents XENON PHARMACEUTICALS INC 2014-03-26 CN disclosed