Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 16/20 | 0.78 |
| ▸ | IGF1R | P08069 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397651 | 0.92 | TNK2 (0.78) | TNK2IGF1RCYP3A4 | |
| SCHEMBL400088 | 0.91 | TNK2 (0.77) | TNK2IGF1RCYP3A4 | |
| SCHEMBL396713 | 0.88 | IGF1R (0.82) | TNK2IGF1RCYP3A4 | |
| SCHEMBL396711 | 0.88 | IGF1R (0.82) | TNK2IGF1RCYP3A4 | |
| SCHEMBL13812431 | 0.88 | IGF1R (0.82) | TNK2IGF1RCYP3A4 | |
| SCHEMBL1129656 | 0.88 | TNK2 (1.00) | TNK2 | |
| SCHEMBL1128890 | 0.88 | TNK2 (1.00) | TNK2 | |
| SCHEMBL4068532 | 0.88 | TNK2 (0.65) | TNK2IGF1RCYP3A4 | |
| Carbamic Acid SCHEMBL4063655 | 0.87 | TNK2 (0.69) | TNK2IGF1RCYP3A4 | |
| SCHEMBL400061 | 0.87 | TNK2 (0.74) | TNK2IGF1RCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102924458-B | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARM INC | 2014-11-05 | — | — | CN | disclosed |