SCHEMBL28811546

SCHEMBL28811546

Cc1c(-n2ccnc2)ccc(-n2ccnc2)c1C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 4/20 0.52
CYP3A4 P08684 6/20 0.48
CYP1A2 P05177 3/20 0.48
CYP2D6 P10635 3/20 0.48
CYP2C9 P11712 3/20 0.48
CYP2C19 P33261 3/20 0.48
GAA P10253 1/20 0.48
LMNA P02545 3/20 0.47
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
MAPT P10636 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
ALDH1A1 P00352 1/20 0.47
MAPK1 P28482 1/20 0.47
PMP22 Q01453 1/20 0.47
CYP11B1 P15538 3/20 0.46
CYP11B2 P19099 3/20 0.46
CYP19A1 P11511 2/20 0.46
ENPP2 Q13822 1/20 0.45
MKNK1 Q9BUB5 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5293242 0.92 IDO1 (0.46) IDO1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL11073181 0.82 CYP3A4 (0.54) IDO1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL28832456 0.79 CYP3A4 (0.51) IDO1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL22797014 0.79 CYP3A4 (0.51) IDO1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL8333563 0.79 CYP3A4 (0.51) IDO1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL27517279 0.79 CYP3A4 (0.60) IDO1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL1885632 0.78 CYP3A4 (0.46) IDO1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL28811547 0.77 NOTUM (0.55) IDO1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL28812903 0.77 IDO1 (0.52) IDO1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL29105016 0.77 IDO1 (0.47) IDO1CYP3A4CYP1A2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114849649-B Ion hybridization porous material with zsd topological structure, and preparation method and application thereof 浙江师范大学 2023-06-02 CN disclosed
CN-114849649-A Ion hybrid porous material with zsd topological structure and preparation method and application thereof 浙江师范大学 2022-08-05 CN disclosed