Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 14/20 | 0.78 |
| ▸ | ABL1 | P00519 | 12/20 | 0.78 |
| ▸ | BCR | P11274 | 8/20 | 0.78 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.78 |
| ▸ | PRKCA | P17252 | 2/20 | 0.77 |
| ▸ | EGFR | P00533 | 2/20 | 0.77 |
| ▸ | KIT | P10721 | 6/20 | 0.72 |
| ▸ | JAK3 | P52333 | 1/20 | 0.68 |
| ▸ | BTK | Q06187 | 1/20 | 0.68 |
| ▸ | ITK | Q08881 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 1/20 | 0.68 |
| ▸ | ABL2 | P42684 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27604250 | 0.89 | ABL1 (0.78) | PDGFRAABL1BCRPDGFRBPRKCA | |
| SCHEMBL12715062 | 0.88 | ABL1 (0.77) | PDGFRAABL1BCRPDGFRBPRKCA | |
| SCHEMBL4803395 | 0.88 | PDGFRA (0.87) | PDGFRAABL1BCRPDGFRBPRKCA | |
| SCHEMBL9820 | 0.88 | PDGFRA (1.00) | PDGFRAABL1BCRPDGFRBPRKCA | |
| SCHEMBL2004455 | 0.88 | PDGFRA (0.91) | PDGFRAABL1BCRPDGFRBPRKCA | |
| SCHEMBL13157377 | 0.87 | ABL1 (0.81) | PDGFRAABL1BCRPDGFRBPRKCA | |
| SCHEMBL3055349 | 0.87 | PDGFRA (0.89) | PDGFRAABL1BCRPDGFRBPRKCA | |
| SCHEMBL3219529 | 0.87 | ABL1 (0.77) | PDGFRAABL1BCRPDGFRBPRKCA | |
| SCHEMBL13498211 | 0.87 | PDGFRA (0.88) | PDGFRAABL1BCRPDGFRBPRKCA | |
| SCHEMBL9782 | 0.87 | PDGFRA (1.00) | PDGFRAABL1BCRPDGFRBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102372690-B | Intermediate for synthesizing imatinib and application of intermediate in imatinib synthesis | CHENGDU DIAO PHARMACEUTICAL GROUP CO LTD | 2014-05-28 | — | — | CN | disclosed |